Advanced drug discovery methods have led to advances in the search for treatments for some neglected tropical diseases, including leishmaniasis and Chagas, but research on schistosomiasis and other diseases caused by worms remains at an early stage, according to an article in Drug Discovery Today by Brazilian researchers.
Research that can increase Brazil’s access to CAR T-cell therapy, an increasingly important strategy for treating cancer, is under way at the University of São Paulo’s Center for Cell-Based Therapy (CTC) in Ribeirão Preto, and the Butantan Institute.
In mice fed a high-fat diet, the molecule mitigated weight gain while reducing insulin resistance and liver fattiness. An article describing the results of the study by researchers at the University of São Paulo and collaborators is published in the International Journal of Molecular Sciences.
In the laboratory, tadpoles of the species B. ibitiguara kept in water 3 °C warmer than the highest temperature recorded in their habitat were unable to complete metamorphosis, indicating a threat to the species from climate change.
Brazilian researchers surveyed 900 volunteers via an online platform for five months. Most reported feeling that time passed more slowly during home confinement in the early months of the pandemic, associating this perception with feelings of loneliness and a lack of positive experiences in the period.
FAPESP and 19 other research foundations will invest BRL 50 million in collaborative science projects aiming at sustainable development in the Amazon.
The material can be used for diagnostic testing, research on the evolution of the monkeypox virus, and development of novel treatments and vaccines.
A delegation from New Zealand led by Education Minister Chris Hipkins visited FAPESP to discuss new partnerships and areas of interest shared by the two countries.
A protocol developed by the Brazil-UK Center for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology (CADDE) was used to analyze a sample from the first Brazilian patient with a confirmed diagnosis. The technology can also be used to detect unknown emerging viruses.
The finding comes from a clinical trial by researchers at the University of São Paulo who recruited 32 male volunteers and have now published the results in Clinical and Experimental Hypertension.
Brazilian researchers have designed a new low-cost anaerobic reactor that uses a bacterial biofilm on a sheet of polyurethane foam. The goal is to enable more wastewater treatment plants in Brazil to achieve nitrogen removal and reduce water body contamination.
Preliminary results of trials conducted by Brazilian scientists show that the existing regulatory framework based on a protocol referenced to the Western honeybee, Apis mellifera, is too Eurocentric and may not be sufficient to guarantee the protection of native bees, which are important pollinators.
Analysis of blood samples showed that sharks living near urban areas have a lower-quality diet than those living in wilderness areas. Dietary imbalances can impair important physiological processes, such as cardiovascular tone, inflammatory response and reproduction.
The approach combined nanotechnology, chemotherapy and monoclonal antibodies. It produced promising in vitro and in vivo results against glioblastoma multiforme.
The workshop was a side event to the Annual Meeting of the Global Research Council. The need to dialogue with and learn from traditional communities, especially Indigenous peoples, was emphasized in the discussions.
Research reveals the mechanisms whereby methionine-deficient and methionine-supplemented diets can alter gene expression and damage liver cells.
A bioink developed from mouse cells can be used in a 3D printer to create a model that more closely resembles the brain than conventional ones. Researchers at the Federal University of São Paulo also obtained an adapted version of SARS-CoV-2 capable of infecting neural cells from mice.
Researchers at the University of São Paulo analyzed data for a group of pregnant women in western Amazonia. The analysis pointed to a correlation between at least 150 minutes of physical activity per week and lower birth weight, with less risk of childhood obesity and diabetes.
The results of a clinical trial are reported by Brazilian researchers in Frontiers in Cardiovascular Medicine. According to the authors, if corroborated by more robust research, the findings indicate that the method can be used in emergency treatment of hypertensive crisis patients.
Universities, research institutions and agencies of the São Paulo State Government will join forces in 15 new centers announced during a ceremony held to celebrate FAPESP’s 60th anniversary. The centers will address problems in areas ranging from human and animal health to the energy transition and climate change.
Monitoring since 2011 shows that emission levels vary significantly from one part of the complex to another, making the standards used in environmental impact assessments and the carbon credit market unreliable.
Mathematic simulations showed that well-executed non-pharmacological measures reduce the spread of COVID-19 even in places with low vaccination coverage. According to the authors, however, up to 80% of the population could catch the disease if preventive protocols are abandoned.
Officially launched on May 18, BIOTA Synthesis is one of FAPESP’s new Science for Development Centers. In the next five years it will develop solutions to challenges relating to sustainable agriculture, water security and control of zoonotic diseases.
The open-access platform developed by researchers at the University of São Paulo offers access to strategic information on microorganisms classified by WHO as a “critical priority”. The aim is to contribute to the monitoring and control of bacteria that pose a great threat to human and animal health.
A startup supported by FAPESP has developed a face cream and body lotion based on cocoa juice, which is usually thrown away. The entrepreneur has been selected for the 2022 Leaders in Innovation Fellowships training program in the UK.
