Researchers at the University of São Paulo found 62 proteins specific to spores of Aspergillus fumigatus, a fungal species that causes lung disease. The study, published in Nature Microbiology, showed that at least one of these proteins inhibits human defense mechanisms.
São Paulo-based startup supported by FAPESP develops cheaper and more sensitive alternative to imported test kits.
Conclusion comes from study that followed more than 4,000 people aged 50 or older for 12 years; damage is mainly in brain areas associated with memory.
Discovery contributes to advances in understanding of the disorder; study is one of the most comprehensive on the subject, with samples from 1,600 patients, including Brazilians.
This particular strain of Klebsiella pneumoniae had previously been detected in the United States. The bacterium frequently causes infections in hospitals, is not eliminated by any existing antibiotic, and is especially dangerous for people with low immunity.
The study was conducted at the Federal University of São Paulo and involved 144 diabetic patients, who were treated with monochromatic infrared light and physical therapy.
Plant-based pigment with antioxidant and anticancer properties breaks down easily in the gastrointestinal tract and under adverse environmental conditions. To avoid the problem, researchers at the University of São Paulo inserted the compound into pectin-coated nanoparticles, enhancing its bioavailability.
Discoveries by Brazilian researchers belonging to a FAPESP-supported research center could lead to strategies to prevent cardiovascular disease associated with diabetes.
A review article by researchers at the State University of Campinas and Baylor College of Medicine discusses relationships between these two conditions, identifying biomarkers that can help clinicians make a differential diagnosis.
The mutations were mapped by a group at the Federal University of São Paulo and collaborators in an analysis of mitochondrial genomes. Thirteen increase the risk of ALS and 38 are protective.
The platform, which was developed with FAPESP’s support, uses a clinical protocol based on cognitive behavioral therapy. The startup responsible participated in a business delegation to FAPESP Week Italy.
Vertical eye movements increased body sway in an experiment involving volunteers with the disease conducted by researchers at São Paulo State University (Brazil) and the University of Lille (France).
Material was compared with conventional dentifrice through in vitro tests on bovine teeth.
In a study of patients with metastatic lung cancer and cachexia, researchers at the University of São Paulo and Harvard Medical School found that treatment was more likely to succeed in physically fitter patients.
One of the raw materials studied by the group is cashew nut shell liquid, a by-product of oilseed processing; work was presented during FAPESP Week Italy.
The study was conducted at the Federal University of São Paulo and involved 731 over-sixties. It is the first to demonstrate the effects of high blood pressure on lung mechanics. The findings highlight the benefits of regular physical exercise for partial protection of the lungs.
Through experiments in mice infected with a herpes virus, scientists identified an immune system sensor that recognizes viral fragments and activates neurons responsible for pain, independently of inflammation. The discovery paves the way for novel analgesic treatments.
Discovery of a novel class of proteins that help regulate the parasite’s essential cellular functions could lead to the development of more effective drugs against the disease. More than 3,500 new cases are notified each year in Brazil.
A study conducted by researchers at the Federal University of São Carlos and University College London analyzed eight years of data for almost 4,000 over-50s.
Nominated in the “Technological Innovation in Oncology” category, the study could benefit patients with hematological neoplasms.
A study conducted by Brazilian scientists at São Paulo State University involved 242 volunteers aged 40 on average. The results showed an improvement in heart rate control by the autonomic nervous system regardless of the level of physical activity in adulthood.
Brazilian researchers analyzed behavioral and physiological factors in animals whose mothers received a synthetic substance that activates the same receptors as marijuana during pregnancy. The consequences were different in males and females.
The synthetic peptide was inspired by ACE2, the protein to which the virus that causes COVID-19 binds to invade human cells. The results point to a route for the development of novel antivirals.
Promising results were obtained by a group at the Brazilian Center for Research on Energy and Materials (CNPEM), working with collaborators elsewhere. They combined inhibition of glutaminase, an enzyme that converts glutamine into nutrients for tumor cells, with inhibition of HuR, a protein that regulates the RNA of glutaminase.
A study conducted at the University of São Paulo in Brazil helps elucidate the impact of high levels of atmospheric carbon dioxide on human health.
