Developed at the University of São Paulo, the model uses protein expression to create a stemness index that analyzes the similarity of tumors to pluripotent stem cells. The article was published in Cell Genomics.
Organoids were developed from the blood cells of centenarians who are part of a project conducted at the Human Genome and Stem Cell Research Center to discover genes that protect the brain from the effects of aging.
Based on the analysis of the genotypes of 500 volunteers, the research project aims to develop a panel of prognostic biomarkers and differentiate Alzheimer’s disease from other types of dementia using blood tests.
In pre-clinical tests conducted at the University of São Paulo, compounds called batzelladins were effective even against strains of Plasmodium that are resistant to conventional antimalarial drugs.
A study by Brazilian scientists shows that a by-product of industrial sunflower oil extraction can be used to produce functional breads with high nutritional value.
FAPESP will begin supporting the Latin American Center for Medical Mycology, a global network of laboratories led by the University of Exeter in the United Kingdom, which also has a unit in South Africa and will soon open another in Asia. Over five years, the foundation will contribute approximately £ 750,000, while the British institution will invest an additional £ 1 million.
In tests with rodents, researchers from the State University of Campinas and their collaborators found that hyperactivation of the PARP1 protein after exhaustive training was associated with decreased performance, fatigue, and behavioral symptoms of overtraining. Animals treated with a drug that inhibits the molecule’s activity did not exhibit the condition.
A pilot intervention project involving playful activities that engaged motor skills and cognition showed promising results in improving eye movements and reading speed in eleven children with dyslexia.
Blood and urine analyses of the population living in the Mundaú lagoon complex revealed a greater presence of chemical contaminants and metabolic alterations that can exacerbate chronic diseases, such as diabetes and hypertension. These results underscore the need to monitor the health of the inhabitants and control the sources of contamination.
The ingredient, extracted from the plant’s seeds, is a good source of protein and has a neutral flavor and aroma, making it easy to use in food products.
Findings published in the International Journal of Biological Macromolecules could guide studies aimed at treating diseases such as osteoporosis.
An experiment conducted at the State University of Campinas showed that FGF19, produced in the intestine, acts on specific regions of the brain, causing the body to burn energy to produce heat; the discovery paves the way for new drugs.
In animal tests, the molecule developed in South America has been shown to prevent fat accumulation and treat existing obesity and associated metabolic disorders. Initial human studies have confirmed the safety of the compound.
The study compared data from patients and healthy individuals from Brazil, Canada, and the United States. The results help paint a clearer picture of how genetics influences the development of OCD.
Researchers from the University of São Paulo have identified a molecule in arachnid venom that acts similarly to a commonly used chemotherapy drug for treating the disease; preliminary results of the study were presented at FAPESP Week France.
Researchers have found a substance in propolis from bees native to Brazil that kills 90% to 100% of Aedes aegypti larvae. The compound, found in pine sap, is likely enhanced by insect processing and has the potential to help combat mosquitoes that transmit arboviruses.
Scientists from the Curie Institute and the University of São Paulo are about to conduct a clinical study to evaluate the safety and efficacy of a new CAR-T cell-based immunotherapy for patients with oculocerebral lymphoma; the project was presented at FAPESP Week in Toulouse.
The evaluation of predictive models for low birth weight cases was based on data from a population study of over 1,500 pregnant women in the city of Araraquara in the state of São Paulo, Brazil. Early identification of the problem is crucial for effective intervention.
With support from FAPESP, the São Paulo startup has developed a molecule that can stimulate the immune system to fight cancer caused by the human papillomavirus; the technology will be presented at the VivaTech fair in Paris.
In a study conducted at São Paulo State University with 80 women over the age of 45, low-dose vitamin D supplementation nearly doubled the treatment response rate.
Rats that exercised and took fatty acid supplements responded better to bacteria and the inflammatory process of apical periodontitis, which can occur when caries reach the root canal and cause an infection.
The system, developed by the FAPESP-supported startup, performs an assessment in eight minutes, drastically reducing the time needed to save lives; the technology will be presented at VivaTech in Paris.
A test developed by the São Paulo state startup with support from FAPESP can distinguish benign nodules from malignant ones; the technology will be presented at one of the largest innovation events in France.
A test developed by the São Paulo state startup with support from FAPESP can distinguish benign nodules from malignant ones; the technology will be presented at one of the largest innovation events in France.
With support from FAPESP, the startup has developed a material containing human umbilical cord stem cells that speeds up the recovery of skin lesions; the technology will be presented at the VivaTech technology fair in France.
