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FAPESP and the Sustainable Development Goals

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SDG 3 Good Health and Well-being

News

SDG 3 Good Health and Well-being

Novel computer simulation method can accelerate COVID-19 drug discovery
SDG 3
Novel computer simulation method can accelerate COVID-19 drug discovery

The technique was used by researchers affiliated with institutions in Brazil, Germany and Finland to study the SARS-CoV-2 main protease (Mpro), a key driver of the virus’s reproductive cycle.


Innovative thyroid nodule diagnostic test avoids unnecessary surgery
SDG 3, SDG 9
Innovative thyroid nodule diagnostic test avoids unnecessary surgery

The molecular test mir-THYpe uses biomarkers to detect whether a thyroid nodule classified as indeterminate is cancerous.


Experimental treatment prevents Alzheimer’s-associated weight gain in mice
SDG 3
Experimental treatment prevents Alzheimer’s-associated weight gain in mice

In a study conducted at a FAPESP-funded research center, a bile acid derivative known by the acronym TUDCA reduced food intake and increased energy expenditure in mice, improving quality of life. The results are promising for humans.


Modified protein from rattlesnake venom permits development of drug to modulate blood clotting
SDG 3
Modified protein from rattlesnake venom permits development of drug to modulate blood clotting

Procedure tested by researchers in Brazil and Belgium made the molecule more stable in the organism. Potential applications include anti-coagulants and wound dressings.


Infection by Chikungunya produces partial immunity against Mayaro virus
SDG 3
Infection by Chikungunya produces partial immunity against Mayaro virus

Scientists at the University of São Paulo confirmed the finding in experiments with mice and blood serum from patients.


Molecules isolated from natural products are strategic to combat neglected diseases
SDG 3
Molecules isolated from natural products are strategic to combat neglected diseases

The point was stressed by participants in the 6th FAPESP 60 Years Conference, featuring experts from Brazil, the UK and the US who discussed the search for drugs to treat diseases that affect some 2 billion people worldwide.


Implementation science contributes to adoption of new practices in public health, specialists say
SDG 3
Implementation science contributes to adoption of new practices in public health, specialists say

Speakers of an online seminar organized by FAPESP detailed methods used to identify and remove barriers that delay or interrupt effective interventions.


Aerobic training offers hypertensives more cardiac benefits in the evening, study suggests
SDG 3
Aerobic training offers hypertensives more cardiac benefits in the evening, study suggests

Scientists at the University of São Paulo compared the effects of morning and evening aerobic exercise on middle-aged men. The results suggest that training between 6 p.m. and 9 p.m. stimulates mechanisms that keep blood pressure fine-tuned.


SARS-CoV-2 increases brain cell energy expenditure in order to replicate
SDG 3
SARS-CoV-2 increases brain cell energy expenditure in order to replicate

Experiments with hamsters and cultured astrocytes point to possible causes of neurological complications in COVID-19 survivors.


Molecule derived from colorant inactivates SARS-CoV-2 and can be used in oral hygiene products
SDG 3
Molecule derived from colorant inactivates SARS-CoV-2 and can be used in oral hygiene products

Collaboration between business and academia in the state of São Paulo proves the virucidal action of iron phthalocyanine and develops a mouthwash containing the compound. In a clinical trial involving patients in the initial stage of infection, the product reduces symptoms and hospital stay.


A webinar discussed Latin American strategies and challenges during the pandemic
SDG 3, SDG 17
A webinar discussed Latin American strategies and challenges during the pandemic

The event was the first of a series of three online seminars organized by FAPESP in partnership with sister agencies in Paraguay and Argentina, under the aegis of the Global Research Council (GRC), with the aim of providing opportunities for an exchange of experiences and cross-border collaboration.


Study reveals factors in metabolism that can enhance efficiency of treatment for gynecologic tumors
SDG 3
Study reveals factors in metabolism that can enhance efficiency of treatment for gynecologic tumors

The findings, published in Gynecologic Oncology, pave the way to the development of a blood test that can be performed by a physician at the time of diagnosis to help personalize treatment.


Scientists discuss use of artificial intelligence to combat COVID-19 and future pandemics
SDG 3, SDG 9
Scientists discuss use of artificial intelligence to combat COVID-19 and future pandemics

Models capable of predicting the spread of pathogens, algorithms that monitor health complaints on social media, and the use of big data and machine learning to speed up drug development were some of the issues discussed by experts who took part in a webinar organized by FAPESP and the Global Research Council.


Study helps understand why obesity increases risk of cardiovascular complications in COVID-19
SDG 3
Study helps understand why obesity increases risk of cardiovascular complications in COVID-19

Brazilian researchers conducted a study of 109 hospitalized volunteers in search of the factors that determine endothelial dysfunction, a condition in which the blood vessels become unable to contract and relax adequately, increasing the risk of heart attack, thrombosis and stroke.


Asphyxia-associated neonatal mortality found to cluster in poorer parts of São Paulo state (Brazil)
SDG 3
Asphyxia-associated neonatal mortality found to cluster in poorer parts of São Paulo state (Brazil)

The methodology used in the study, which is published in PLOS ONE, can help policymakers plan strategies for preventing deaths of babies under 28 days old.


Change in vaccination strategy averted outbreak of urban yellow fever in São Paulo, scientists say
SDG 3
Change in vaccination strategy averted outbreak of urban yellow fever in São Paulo, scientists say

An article in Scientific Reports shows that the virus spread at a speed of 1 km per day in the latest sylvatic outbreaks in the state, between 2016 and 2019, reaching cities never affected before. The authors warn that the situation could recur.


Study identifies genes that are altered in Crohn’s disease patients
SDG 3
Study identifies genes that are altered in Crohn’s disease patients

Analysis of tissue samples showed the presence of cells that can trigger the inflammatory process typical of Crohn’s. The study paves the way for the detection of biomarkers that can help predict evolution to the severe form of the disease, and for more precise diagnosis.


Highly abundant virus in humans could be a biomarker for COVID-19
SDG 3
Highly abundant virus in humans could be a biomarker for COVID-19

A study conducted at the University of São Paulo shows that levels of TTV, an apparently inoffensive virus considered an indicator of immunodepression, tend to be higher in people infected by SARS-CoV-2. TTV load declines as the symptoms of COVID-19 disappear, the researchers write in PLOS ONE.


Cardiopulmonary exercise testing can be used for early detection of respiratory disorders in the obese
SDG 3
Cardiopulmonary exercise testing can be used for early detection of respiratory disorders in the obese

A study by researchers at the Federal University of São Paulo shows test results are highly applicable in practice to identify exercise limitation, regardless of overweight or obesity.


Heparin dose capable of preventing COVID-19 deaths is four times higher than the dose recommended by WHO
SDG 3
Heparin dose capable of preventing COVID-19 deaths is four times higher than the dose recommended by WHO

This is one of the main findings of a clinical trial involving 465 patients at 28 hospitals in six countries, including Brazil. The likelihood of dying was 78% lower for the group given a therapeutic dose of the anti-coagulant.


Opportunistic bacterium increases its virulence by ‘poaching’ zinc and iron from hosts
SDG 3
Opportunistic bacterium increases its virulence by ‘poaching’ zinc and iron from hosts

Researchers at the University of São Paulo have unraveled the strategy used by Chromobacterium violaceum, a pathogen found in water and soil in tropical and subtropical regions, to increase its capacity to replicate and infect host organisms. The discovery offers a route for the development of novel therapies.


Novel rapid test detects SARS-CoV-2 in saliva and indicates viral load
SDG 3
Novel rapid test detects SARS-CoV-2 in saliva and indicates viral load

The portable device developed at the Federal University of São Carlos is as accurate as RT-PCR, the gold standard for diagnosing COVID-19, and can analyze up to 20 samples at the same time.


Exercise training reverses muscular atrophy caused by cancer and can extend patient lifespan
SDG 3
Exercise training reverses muscular atrophy caused by cancer and can extend patient lifespan

A study in rats by researchers at institutions in Brazil, the US and Norway investigated the effects of physical exercise on cancer cachexia. The analysis suggested that exercise training can be an ancillary treatment for cancer patients.


Startup launches cosmetic made from passion fruit bagasse
SDG 3, SDG 9
Startup launches cosmetic made from passion fruit bagasse

Researchers recombined extracts from this fruit industry waste to produce a mini-emulsion that can be used as the basis for an anti-aging skin complex.


Large infrastructure projects in the Amazon have bequeathed a harmful social and environmental legacy
SDG 1, SDG 3, SDG 8, SDG 13
Large infrastructure projects in the Amazon have bequeathed a harmful social and environmental legacy

For scientists gathered at this FAPESP-hosted webinar, projects like the Belo Monte dam and the Transamazon highway have had few local benefits and led to a rise in poverty, violence, deforestation and disease.


News about research projects funded by FAPESP and articulated with the SDGs: