In experiments with rats, researchers at the University of São Paulo analyzed brain tissue and detected alterations in genes associated with energy metabolism.
In experiments with rats, researchers at São Paulo State University detected changes in the expression of more than 700 genes in offspring. One of these genes is known to be associated with prostate cancer.
Some species of cetacean are up to 4 meters in length, while others reach 30 meters. According to researchers at the State University of Campinas, genes that favor the colossal growth of these mammals also inhibit the development of cancer.
Researchers at the University of São Paulo and São Paulo state’s Center for Epidemiological Surveillance observed spatial and temporal patterns of occurrence and co-occurrence for the two arboviral diseases in all Brazilian municipalities, alongside the influence of environmental and socio-economic factors.
A study involving 20 women with rheumatoid arthritis and high blood pressure demonstrates the benefits of walking at moderate speed for 30 minutes even after tests that simulate stressful situations and tend to raise blood pressure.
The device is under preclinical trials; the sponge is made of soft, biodegradable material and releases medication slowly into the organism.
The kit is designed to be used for screening. If the result is negative, it should be repeated a year later. If positive, the individual should see a specialist.
Researchers at the University of São Paulo identified in mice the neurons associated with the anxiolytic effect of growth hormone. Their discovery paves the way for the development of novel classes of medications for neuropsychiatric disorders.
Fragments of hemorrhagic toxins that may help treat high blood pressure were found in the venom of the pit viper Cotiara, which inhabits the South of Brazil, and that of the South American bushmaster, a denizen of tropical rainforests. The molecules might one day be used in drugs with fewer adverse side effects.
A survey conducted in a Brazilian state with the country’s second-highest number of ophidic accidents draws attention to the need to train health workers to complete notification forms correctly. Better data will help improve research and antivenom distribution.
Researchers at São Paulo State University tested the action of nanoparticles loaded with antibiotics and other antimicrobial compounds on cells infected by the bacillus that causes tuberculosis. The results suggest the strategy can overcome multidrug bacterial resistance.
The study is the first-ever demonstration of the anatomical substrate for the cardiac arrhythmias that occur in human yellow fever.
Brazilian researchers analyzed air pollution in metropolitan São Paulo in 2019-20 when mobility restrictions and social distancing applied in the southern hemisphere’s largest city. Even so, the daily average exceeded the World Health Organization’s air quality standard on 75 days.
A review article by Brazilian researchers lists recent discoveries on this chronic inflammatory skin disease, which affects around 10% of adults and 25% of children.
A study conducted at the University of São Paulo’s Optics and Photonics Research Center in Brazil showed a change in the bacterium’s sensitivity after five applications.
Infection by SARS-CoV-2 can suppress the expression of mitochondrial genes involved in production of ATP cell fuel in many vital organs. The discovery paves the way to a search for strategies to restore mitochondrial function.
Scientists in Brazil have tested a method to obtain a substance similar to estrogen from soy isoflavones. They aim to create a product that reduces the discomfort suffered by many women in the menopause.
Results of tests with the substance pave the way for the development of medications or specific vaccines against zika, for which there is currently no treatment. The number of cases rose 20% year on year in the first seven months of 2023.
In an article published in the Journal of Applied Physiology, researchers at the University of São Paulo show that damage to small blood vessels in the lungs caused by SARS-CoV-2 is the main factor underlying severe COVID-19.
Technology developed by a startup supported by FAPESP has been used to improve the performance of athletes like soccer goalkeeper Ederson, who plays for Manchester City and Brazil’s national side, and to reduce the number of accidents caused by human error in the petrochemical and meatpacking industries.
Called SpiNTec, the vaccine can induce a more lasting immune response and should be more effective than vaccines currently available in Brazil against variants of the novel coronavirus SARS-CoV-2, according to the leader of the local vaccine development project, who took part in the FAPESP 2023 School in Exact and Natural Sciences, Engineering and Medicine.
In vitro experiments showed cobalt-doped calcium phosphate to be capable of stimulating bone cell differentiation by mimicking a low-oxygen environment. Next steps include animal testing.
The Ninth General Assembly of the Global Research Collaboration for Infectious Disease Preparedness, representing funding agencies, research institutions and government bodies from around the world, was held at FAPESP in São Paulo, Brazil, on October 24-25.
Scientists at the University of São Paulo’s Center for Research on Redox Processes in Biomedicine used a novel technique they themselves developed to identify altered molecules in an animal model of amyotrophic lateral sclerosis (ALS).
The emergence of rabies in distinct wildlife species is a potential source of human infection and poses life-threatening risks. As the researchers responsible for the discovery warn, anyone who comes into contact with these animals should alert the authorities. A 36-year-old farm worker died in May, only weeks after being bitten by a marmoset.
