Study in hamsters paves way for development of nasal sprays and other products to fight several viral diseases, including HIV/AIDS, shingles and influenza.
The conclusion comes from a study that followed 805 Brazilians in their 50s for eight years. The results underscore the need for increased attention to hearing health as a way to prevent dementia.
Through experiments with mice, scientists from the State University of Campinas have shown that physical activity induces immune cells involved in the inflammatory process to acquire an anti-inflammatory profile. The finding opens the way to new therapeutic approaches.
A study conducted at the Federal University of São Paulo compared the performance of people diagnosed with primary progressive aphasia and healthy individuals, identifying the main tasks that can signal the presence of the syndrome.
Analysis of the gut microbiota of more than 700 babies also showed that breastfeeding was a protective factor, mitigating the problem in those who consumed industrialized products. The study underscores the importance of breastfeeding and avoiding foods high in sugar, saturated fat, salt and chemical additives.
This is the finding of a study that followed 352 pairs of newborns and their mothers in the cities of Guarulhos and São Paulo (Brazil). Changes observed in the first two months of life may increase future risk of obesity and diabetes.
The rodent experiment, conducted at the State University of Campinas, highlighted the involvement of the hnRNP A1 molecule in maintaining the integrity of the myelin sheath – a fatty layer that protects neurons and facilitates communication between them. The findings pave the way for potential therapies.
Researchers from the Federal University of São Paulo and the Butantan Institute are working on an improved version of the antibothropic serum, with more neutralizing antibodies and fewer proteins associated with side effects.
Results from a FAPESP-supported research center pave the way for expanding the use of photodynamic therapy in the fight against skin cancer.
While cognitive-behavioral therapy showed faster results, the effect of acceptance and commitment therapy was more lasting, shows a study conducted at the University of São Paulo with 227 volunteers.
Rodents fed a diet rich in soluble fiber coped better with a microorganism that causes diarrhea and can lead to death in debilitated patients. Researchers observed that acetate – a compound produced by the gut microbiota when fiber is digested – helps modulate the immune response.
Equipment developed in Brazil by researchers at the National Telecommunications Institute combines Internet of Things devices, high-resolution cameras, and artificial intelligence algorithms to capture and identify female Aedes aegypti without harming other insects.
Device developed with the support of FAPESP is more accurate than assessments made by doctors using a dermatoscope.
Researchers from São Paulo State University and collaborators studied 50 young people with an average age of between 26 and 27. The goal was to find biomarkers that allow early detection of health changes.
An enzyme cloned from an insect found by Brazilian researchers – and genetically modified – makes it possible to monitor intracellular acidity and could be used to study diseases and drugs.
The study, conducted at the State University of Campinas, involved 44 people with mild cognitive impairment. After six months, the volunteers who practiced strength training showed improvements in memory and brain anatomy, while the others showed a decline in the parameters evaluated.
Researchers from Brazil and Germany study the mechanism of action of phytochemicals from papaya, passion fruit and medicinal plant extracts; results were presented at FAPESP Week Germany.
This is the conclusion of a study conducted at the University of São Paulo with 23 volunteers. The data show that only evening workouts regulated so-called baroreflex sensitivity – a mechanism that compensates for sudden changes in blood pressure.
In a study of 130 volunteers conducted at the Federal University of São Carlos, a drastic decrease in heart rate variability, i.e. the heart’s ability to adapt to environmental and physiological demands, was observed – up to six weeks after infection.
In rodent experiments, a cellulose product with silver nanoparticles was able to reduce microbial colonies in skin lesions, speeding up healing; treatment could benefit people with diabetic foot, burns, and bedridden patients with pressure ulcers.
In experiments conducted at the University of São Paulo, tumor stem cells became less able to proliferate and invade tissues when the production of the prion protein was blocked by gene editing; the results suggest that the molecule could be a therapeutic target.
Researchers tested different concentrations of the substance on dental pulp cells. Results show promise for dental tissue repair.
Material shows potential for use in drug delivery and tissue support systems in the human body.
Brazilian researchers have conducted a comprehensive study of the effects of seizures during development. The findings could lead to new treatments for autism, attention deficit disorder, schizophrenia and epilepsy.
Research conducted at the Butantan Institute seeks to identify a compound that can be used in both the prevention and treatment of arboviruses.
