Researchers at the University of São Paulo in Brazil compared data for the immune response induced by natural infection and vaccines. They identified the key factors in the development of long-lasting immunity. Their findings can be used to develop novel vaccines and antiviral therapies.
An international team including virologists, physicians, epidemiologists, clinicians, physicists and statisticians has discovered new mechanisms related to central nervous system infection in fatal cases of the infection. The results were published in the journal Cell Host & Microbe.
The findings, published in Psychiatry Research, are an important contribution to both the understanding of mental disorders and suicide prevention.
After inducing mutations in the genotypes of mice and analyzing their effects on several generations of descendants, Brazilian and American researchers mapped the genetic determinants essential to an understanding of cardiovascular disease. Their findings are published in the journal Science Advances.
A formulation developed by Brazilian researchers proved effective in tests involving mice.
The correlation between these two symptoms of the disease was observed by researchers affiliated with institutions in Brazil and France in a systematic review of 20 studies.
Patricia LoRusso, President of the American Association for Cancer Research (AACR), gave Agência FAPESP an exclusive interview during a visit to Brazil. She spoke about the importance of attracting early-career researchers to oncology, the future of clinical cancer research, and potential new discoveries in the field.
The device was developed by researchers at the University of São Paulo’s Heart Institute (INCOR) and a Brazilian company with FAPESP’s support. It is biocompatible and offers other advantages over the imported product used hitherto.
An electrode with films of iridium dioxide and niobium oxide on a titanium substrate removed molecules of the drug levofloxacin, considered an emerging pollutant.
For three months, Brazilian researchers tracked 74 patients submitted to 12 sessions lasting 15 minutes each and observed remission of symptoms. The ancient Chinese practice had no side effects, according to an article on the study published in JAMA Network Open.
The methodology was developed by Brazilian and British researchers, who tested it in Campinas, a large city in São Paulo state. Its aim is to optimize monitoring and combating the mosquito Aedes aegypti.
Brazilian and British researchers analyzed data for 1,747 older participants tracked by ELSA over a period of 12 years, and mapped the different routes that can lead to a negative outcome. They advocate use of their findings by policymakers.
An interdisciplinary approach tested at the Federal University of São Paulo combined clinical, nutritional, psychological and exercise counseling. The intervention involved remote and in-person sessions, favoring adherence and lowering the cost to the health system.
In animal tests conducted at São Paulo State University (UNESP), the strategy reduced spleen and liver parasite numbers by 99.9%.
Researchers at the University of São Paulo analyzed data from 115 children who suffered from conditions considered syndromic (with several associated symptoms) and found a high incidence of overlapping genetic alterations. They argue that identification of genetic mutations can make diagnosis and treatment more accurate.
The opossum was found dead in a park in the center of Campinas, a large city in São Paulo state (Brazil), with the same viral variant as fruit-eating bats. These mammals are regularly detected in cities, where they are often attacked by dogs, so they can be considered sentinel species for infectious disease surveillance.
Through experiments in roundworms of the species C. elegans, scientists at a FAPESP-supported research center showed that lifespan is reduced when RNA transfer between cells in different tissues is dysregulated.
Blood pressure rose in offspring born to high-fructose rats, and physiological regulation of their cardiovascular system was impaired. High-fructose syrup is widely used as a sweetener by the food and beverage industry.
A study led by Brazilian researchers suggests that the mechanism that exacerbates dengue infection following a case of zika differs from that acting on second-time dengue patients. The finding is relevant to the development of a zika vaccine.
A study conducted at a FAPESP-supported research center discovered a link between the protein VAPB and tumor cell proliferation in medulloblastoma, one of the most common and aggressive brain tumors in children.
The analysis compared the effects of artepillin C on healthy cells and cancer cells, as well as the effects on its efficacy of variations in the medium’s pH.
CD4+ T cells play an important role in the immune response to pulmonary infections, but excessive amounts can damage the lungs. In experiments with mice, researchers at the University of São Paulo discovered what leads to this exacerbated response.
Data from the Phase 3 clinical trial was published on February 1st in The New England Journal of Medicine. The vaccine is safe for both participants who have had dengue and those who have never been exposed to the virus before.
Developed by a team of Brazilian researchers, the device is made of plant-based material with little environmental impact, and detects pesticides in a few minutes, helping to certify food safety.
In 18 cities of the Barretos region, where the proportion of Black people in the population is smaller, cancer kills more members of this ethnic group, whereas in the capital of the same state, it kills more White people, according to a study that compares cancer mortality rates and points to ways of reducing inequalities in diagnosis and treatment.
