At a meeting held in São Paulo city, researchers from the Brazilian state of São Paulo and the Netherlands described their work on the development of prosthetics and other implantable biomaterials. FAPESP will invest BRL 15.2 million to fund the projects selected in the call.
Researchers at the University of São Paulo tested the anthelmintic niclosamide on mice and human blood cells. In addition to exhibiting antiviral action, the drug deactivated the cellular mechanism that triggers a cytokine storm. A novel formulation is required for the active principle to reach the lungs and treat severe COVID-19 in humans.
Measuring handgrip strength is one of the main ways of detecting sarcopenia, a syndrome characterized by loss of muscle mass, force and function. Researchers in Brazil and the UK recommended raising the minimum value considered normal, after analyzing data for more than 6,000 men and women aged 60 and over.
Analysis of skin tumor samples showed correlations between changes in proteins that regulate the organism and prognosis. The results, published in Nature Communications, were obtained by researchers in Brazil and France.
The results of animal trials were published recently in Nature Communications. The researchers have received the green light from the national health surveillance authority to proceed with testing on humans.
Researchers at the University of São Paulo analyzed air samples collected near the hospital complex run by its medical school and found that the more plastic they contained, the higher the viral load. The results of the study suggest SARS-CoV-2 binds to microplastic and more easily enters the upper airways and lungs.
Research by groups at the University of São Paulo and the State University of Campinas combined MRI scans of the brains of mild COVID-19 patients, analysis of brain tissue from people who died of the disease and experiments on human nerve cells infected in the laboratory.
A study published in the journal Vaccines used samples from blood banks in seven Brazilian state capitals to measure levels of SARS-CoV-2 antibodies and the extent to which vaccines afford protection against the delta variant.
Twenty-one patients with metabolic syndrome were given a calorie or protein restriction diet in a randomized clinical trial by Brazilian and Danish researchers. Weight loss, controlled blood pressure and improved blood sugar and lipid levels were observed in all participants.
A study by Brazilian researchers analyzed risk factors and found that reducing smoking prevented most deaths from cardiovascular disease, while high blood sugar had the most significant impact on mortality.
Proteomic analysis suggests zika virus causes alterations in the expression of proteins linked to the metabolism of developing neural cells, and proteins associated with the maturation of oligodendrocytes.
The study involved the use of biosensors, algorithms and open-source software to build a miniature microscope. The findings contribute to a better understanding of how our brains track and retain information about routes and learn new locations.
The results of a study conducted by Brazilian researchers will be useful both for epidemiological surveillance and to improve the treatment available to patients. An article on the study is published in PLOS ONE.
An international group of scientists presents this conclusion in an article in Nature Microbiology, warning that novel antifungal medications are urgently.
The topic was discussed on August 9 by Barry O’Keefe of the US National Cancer Institute during the FAPESP 60 Years School on Exact, Natural and Life Sciences. The other speakers on the second day of the event were José Nelson Onuchic of Rice University and Virgilio Almeida of the Federal University of Minas Gerais.
The combination is particularly dangerous for women, according to a study by researchers in Brazil and the UK who analyzed data for 5,310 people aged 50+ followed in a ten-year health survey.
The type of ependymoma studied mainly affects children, has a low survival rate and has no specific chemotherapeutic treatment. A combination of two experimental drugs inhibited tumor growth in vitro.
Researchers at the University of São Paulo in Brazil fed data for different coronaviruses into a machine learning model. The results reinforced the role of flying mammals as the first reservoirs of the virus that caused the COVID-19 pandemic. The tool can be used in future emergencies.
While some patients die with a high viral load and little inflammation, others succumb to inflammatory complications that arise after the virus is eliminated from the organism. According to scientists at the University of São Paulo, lasting inflammasome activation is key in such cases. The findings can be used to develop personalized therapeutic approaches.
In a webinar held to present the third chapter of the book published by the São Paulo State Academy of Sciences to commemorate FAPESP’s sixtieth anniversary, specialists showed that protection of terrestrial and marine environments contributes to food production and job creation, among other benefits.
A study published in Lancet Regional Health – Americas will help improve actions to combat this public health problem in the North of Brazil.
Researchers at the University of São Paulo in Brazil followed up hundreds of COVID patients after discharge from hospital in São Paulo City. Tests conducted six months later showed that those with the most severe sensory disorders also performed worse in tests of cognitive functions, especially memorization.
Researchers at the University of São Paulo tested a therapeutic intervention that proved capable of reducing the mortality rate from MA-ARDS in experiments on mice. The findings point to an avenue for the development of novel treatments for human patients.
Researchers at the University of São Paulo showed, through experiments on animals and genetically modified cells, that this type of cancer advances more slowly when the light-sensitive molecule known as melanopsin is deactivated. The discovery could point to novel therapeutic strategies.
Double-strand DNA breaks cause cell damage in several organisms, but apparently play a key role in the lifecycles of species that cause Chagas disease, sleeping sickness and leishmaniasis. The results of the study pave the way to the development of more effective treatment.
