In experiments involving rats, researchers at São Paulo State University found that periods of low oxygen levels in the first months of life can lead to dysregulation of the sympathetic autonomic nervous system, which controls functions such as heart rate and blood pressure. The discovery points to possible routes to the development of novel therapies.
A biodressing containing human umbilical cord stem cells was produced in a 3D printer by the startup In Situ Cell Therapy. Researchers at the University of São Paulo found that when used on diabetic mice, the “smart” biodressing modulated the immune response, stimulated collagen synthesis and enhanced tissue repair.
Leishmania alters the structure of the human protein that would normally induce the death of infected cells and weakens the inflammatory response. Reported in Nature Communications, the discovery could serve as a basis for better treatment.
An analysis conducted at the University of São Paulo showed that no sample exceeded the recommended limit for aflatoxin M1, a contaminant of fungal origin considered carcinogenic. Nevertheless, the researchers warn of the need to demand best practices in dairy production.
A study by researchers at the State University of Campinas showed that although the two types of training produce similar metabolic stress, muscle activation is different.
Brazilian researchers observed an increase in production of endocannabinoid, a natural anti-inflammatory neurotransmitter, in COVID-19 patients given glucocorticoids. The discovery points to possibilities of novel treatments for various inflammatory and neurological diseases.
Scientists at São Paulo State University repurposed a device already used to analyze bovine reproductive cells to observe different characteristics of human sperm simultaneously.
In vitro experiments were conducted at a FAPESP-supported research center with a synthetic peptide inspired by molecules secreted by the probiotic bacterium Lactobacillus plantarum.
A program developed by researchers at the University of São Paulo included three weekly sessions of up to 80 minutes each for 16 weeks, with positive effects on cardiorespiratory fitness, lung function, functional capacity, body composition and persistent symptoms.
Predictive model developed at São Paulo State University (UNESP) helps identify tumor biomarkers of this metabolic syndrome characterized by acute weight loss and muscle wasting.
In laboratory mice, the hormone easily bought from pharmacies and widely consumed as a supplement aggravated Crohn’s disease and ulcerative colitis, depending on the animal’s gut microbiota profile, according to a study by researchers at the University of São Paulo.
Researchers show the importance of political skill on the part of federal research institution Fiocruz and regulatory agency ANVISA in the process that resulted in the signature of an agreement with pharmaceutical company AstraZeneca in mid-pandemic.
In a study with 116 participants, researchers at the Federal University of São Paulo evaluated the genetic material contained in extracellular vesicles possibly secreted by brain tissue. The analysis pointed to patterns of microRNA expression associated with depression, anxiety and ADHD.
Researchers in Brazil and Portugal have been following patients under 40 who had the disease before being vaccinated. Alterations found in immune cells up to 180 days after infection resemble those found in patients with chronic diseases.
This was the main finding of a study involving rats conducted by Brazilian researchers. Mortality was 29% higher for fetuses exposed to a synthetic compound that acts on the brain in a similar manner to natural cannabinoids. Respiratory control and CO2 sensitivity, which influence sudden infant death syndrome, were also altered.
With the support of FAPESP’s Science for Development Center Program, the unit hosted by São Paulo State University will produce pilot batches of candidate biopharmaceuticals and vaccines for clinical trials. The aim is to help researchers and startups survive the “valley of death” in clinical research.
Researchers at the University of São Paulo analyzed placental samples from women with and without obesity who contracted the infection while pregnant. The results show that maternal overweight can compromise the placenta’s immune response and impair fetal protection.
Working at the University of São Paulo in Brazil, the researchers used epigenetics to study the mechanism, which could be associated with pathologies such as Alzheimer’s. The discovery expands scientists’ knowledge of the central nervous system.
Developed at the University of São Paulo, the device permits corrections to the dosage of the analgesic to improve its efficacy according to the patient’s profile and avoid toxic side effects or overdose.
The device, produced by ordinary 3D printing and capable of being miniaturized, detects levels of the protein PARK7/DJ-1, which is associated with the disease. The study used samples of blood serum and cerebrospinal fluid.
A study by a group at the University of São Paulo reported in a scientific journal involved the construction of a database and models. Preliminary results are described in the article.
Deletion of two genes, which in mice attenuated the action of the bacteria, made the immune response more exacerbated in broiler chicks. The findings reinforce the need for animal health and hygiene measures throughout the poultry production chain.
The finding is from a longitudinal study conducted in Brazil. Analyzing data for high school students aged 13-18, it concluded that the problem affects girls more than boys and is associated with physical inactivity and low academic achievement.
The center will be hosted by the Federal University of Ceará and will focus on the use of the Internet of Things, big data, digital transformation and cutting-edge technology in prevention, diagnosis and low-cost therapies.
Addition of rosmarinic acid at a mere 0.1% reduced the amount of sunscreen needed to protect the skin, increased the sun protection factor by more than 41% and combined photoprotection with antioxidant activity. The innovation would reduce the volume of chemical substances discharged into the environment.
