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FAPESP and the Sustainable Development Goals

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SDG 3 Good Health and Well-being

News

SDG 3 Good Health and Well-being

High dose of vitamin D fails to improve condition of moderate to severe COVID-19 patients
SDG 3
High dose of vitamin D fails to improve condition of moderate to severe COVID-19 patients

A clinical trial was conducted by researchers at the University of São Paulo with 240 patients who were given 200,000 IU of vitamin D3 on admission to hospital. The supplementation did not reduce length of stay or affect the proportion requiring intensive care.


Researchers revise indicator of mobility limitation in older adults
SDG 3
Researchers revise indicator of mobility limitation in older adults

The new cutoff values for a metric widely used by geriatricians, physical therapists and nutritionists are more accurate, facilitate early diagnosis and contribute to preventive treatment.


Test classifies thyroid nodule with superior sensitivity
SDG 3, SDG 9
Test classifies thyroid nodule with superior sensitivity

By means of specific biomarkers, a diagnostic test developed by the Brazilian startup Onkos shows whether a lump in the gland is benign or malignant, reducing the risk of unnecessary surgery.


Online tool facilitates monitoring of COVID-19 epidemic in Brazil
SDG 3, SDG 9
Online tool facilitates monitoring of COVID-19 epidemic in Brazil

The platform developed by researchers from Brazil and Chile lets users view geolocation of cases, deaths and vaccinations over time.


SARS-CoV-2 inhibits removal of dead cells by the immune system, favoring lung damage
SDG 3
SARS-CoV-2 inhibits removal of dead cells by the immune system, favoring lung damage

A study by the University of São Paulo has discovered that when macrophages engulf cells infected by the novel coronavirus, they begin producing excessive amounts of pro-inflammatory molecules, and their capacity to recognize and phagocytize dead cells is reduced twelvefold.


Novel coronavirus can remain active for more than 14 days in patients with mild symptoms
SDG 3
Novel coronavirus can remain active for more than 14 days in patients with mild symptoms

Brazilian researchers monitoring the population of metropolitan São Paulo have reported atypical cases in which SARS-CoV-2 continues to replicate in the organism for longer than the recommended isolation period.


Researchers develop a technique to produce transplantable livers in the laboratory
SDG 3, SDG 9
Researchers develop a technique to produce transplantable livers in the laboratory

A method created in Brazil by the Human Genome and Stem Cell Research Center could be used for large-scale production of livers for transplantation.


São Paulo-based firm creates “artificial lung” to treat COVID-19
SDG 3, SDG 9
São Paulo-based firm creates “artificial lung” to treat COVID-19

Extracorporeal membrane oxygenation (ECMO) can keep patients alive until the disease recedes.


High-fiber diet may play a role in controlling the inflammation associated with COVID-19
SDG 3
High-fiber diet may play a role in controlling the inflammation associated with COVID-19

Brazilian researchers treated cells infected by SARS-CoV-2 with compounds produced by gut microbiota from dietary fiber. The intervention did not mitigate viral replication but reduced expression of a gene that plays a key role in viral entry into cells and a receptor involved in the inflammatory process.


Brazilian researchers obtain more efficient red bioluminescence
SDG 3, SDG 9
Brazilian researchers obtain more efficient red bioluminescence

Luciferin-luciferase system developed in collaboration with Japanese researchers produces brighter and longer-lasting far red light. The innovation can be used to image cells and tissues for diagnosis and biomedical research.


Preliminary study suggests CoronaVac neutralizes novel variants of SARS-CoV-2
SDG 3
Preliminary study suggests CoronaVac neutralizes novel variants of SARS-CoV-2

Laboratory trial by Butantan Institute in partnership with the University of São Paulo involved inoculation of variants P.1 and P.2 into cultured cells containing blood serum from vaccinated subjects. The results were satisfactory, according to the researchers.


Brazilian startup develops remotely operated room sterilization device
SDG 3, SDG 9
Brazilian startup develops remotely operated room sterilization device

The technology uses ultraviolet-C, which can inactivate the novel coronavirus. Startup BioLambda was supported by FAPESP and partnered with the Albert Einstein Jewish-Brazilian Hospital in São Paulo.


Study could help develop biosensors for non-invasive diagnosis of diseases
SDG 3, SDG 9
Study could help develop biosensors for non-invasive diagnosis of diseases

Brazilian researchers tested the capacity of different materials to produce sensors for the detection of PCA3, a gene that is overexpressed in prostate cancer. The technique can also be used to diagnose infectious diseases, including COVID-19.


Researchers discover inflammatory mechanism responsible for bone erosion in rheumatoid arthritis
SDG 3
Researchers discover inflammatory mechanism responsible for bone erosion in rheumatoid arthritis

In a study of the effects of cigarette smoking on exacerbation of the disease, scientists at a FAPESP-supported research center identified a novel pathway in the inflammatory process relating to bone damage.


Amazon strain of coronavirus already predominates in cases of COVID-19 in a city 2,500 km from Manaus
SDG 3
Amazon strain of coronavirus already predominates in cases of COVID-19 in a city 2,500 km from Manaus

In Araraquara, state of São Paulo, researchers detected the P.1 variant in 93% of samples from patients diagnosed at a primary healthcare facility in the first two months of the year.


Antibodies against SARS-CoV-2 induced by prior infection are six times less effective against P.1 variant
SDG 3
Antibodies against SARS-CoV-2 induced by prior infection are six times less effective against P.1 variant

Blood plasma from COVID-19 convalescents was tested against Brazilian variant isolates obtained from patients diagnosed in Manaus. The study also assessed the effectiveness of plasma from volunteers immunized with CoronaVac.


Study suggests the Brazilian variant emerged in November, is more transmissible and can cause reinfection
SDG 3
Study suggests the Brazilian variant emerged in November, is more transmissible and can cause reinfection

Published by an Anglo-Brazilian epidemiological research center, the study revealed that in only seven weeks SARS-CoV-2 lineage P.1 became the most prevalent strain of the virus in Manaus. Analysis of more than 900 samples from patients diagnosed in the period pointed to a higher viral load.


Project investigates remote control of enzymes using light
SDG 3
Project investigates remote control of enzymes using light

In a study conducted at the University of São Paulo, researchers used infrared laser irradiation to accelerate the activity of enzymes immobilized on gold nanoparticles. The technique could have biomedical and industrial applications.


COVID-19 Data Sharing/BR makes more datasets available
SDG 3
COVID-19 Data Sharing/BR makes more datasets available

Open-access repository established to facilitate research on the disease holds anonymized data including clinical examinations and laboratory test results from 485,000 patients processed by five institutions.


Molecule with potential to treat multiple sclerosis and asthma passes toxicology testing in zebrafish
SDG 3
Molecule with potential to treat multiple sclerosis and asthma passes toxicology testing in zebrafish

Study conducted at a FAPESP-supported research center shows that anti-inflammatory peptide TnP could lead to drug development.


Deforestation in the Amazon favors an increase in the diversity of antibiotic-resistant soil bacteria
SDG 3
Deforestation in the Amazon favors an increase in the diversity of antibiotic-resistant soil bacteria

Study suggests that replacing native vegetation with pasture or crops increases competition among microorganisms, favoring those with antimicrobial resistance genes. Brazilian scientists advocate more research to find out whether bacteria can migrate to food and reach humans.


Study suggests shortening quarantine for people infected by novel coronavirus to ten days would be risky
SDG 3
Study suggests shortening quarantine for people infected by novel coronavirus to ten days would be risky

In October the CDC recommended ten instead of 14 days of isolation for patients with mild or moderate symptoms, but Brazilian researchers found viable viral particles in 25% of samples collected from patients on the tenth day of symptoms.


Innovative cancer treatment found to be a promising approach to the control of fungal infections
SDG 3
Innovative cancer treatment found to be a promising approach to the control of fungal infections

The use of CAR T-cells reprogrammed to “recognize” Cryptococcus spp. proved effective to combat the infection in vitro and in mice.


Models to predict dengue, zika and yellow fever outbreaks are developed by international research group
SDG 3
Models to predict dengue, zika and yellow fever outbreaks are developed by international research group

Scientists will monitor areas in which these diseases are endemic, such as São Paulo, the Amazon, the Pantanal and Panama, to investigate the factors that trigger outbreaks.


Structure of novel coronavirus inspires design of nanoparticles for drug delivery
SDG 3, SDG 9
Structure of novel coronavirus inspires design of nanoparticles for drug delivery

According to a paper by Brazilian researchers published in Nano Today, the spatial arrangement of proteins on the surface of SARS-CoV-2 assures highly efficient interaction with target receptors on human cells.


News about research projects funded by FAPESP and articulated with the SDGs: