A study published in Lancet Regional Health – Americas will help improve actions to combat this public health problem in the North of Brazil.
Researchers at the University of São Paulo in Brazil followed up hundreds of COVID patients after discharge from hospital in São Paulo City. Tests conducted six months later showed that those with the most severe sensory disorders also performed worse in tests of cognitive functions, especially memorization.
Researchers at the University of São Paulo tested a therapeutic intervention that proved capable of reducing the mortality rate from MA-ARDS in experiments on mice. The findings point to an avenue for the development of novel treatments for human patients.
Researchers at the University of São Paulo showed, through experiments on animals and genetically modified cells, that this type of cancer advances more slowly when the light-sensitive molecule known as melanopsin is deactivated. The discovery could point to novel therapeutic strategies.
Double-strand DNA breaks cause cell damage in several organisms, but apparently play a key role in the lifecycles of species that cause Chagas disease, sleeping sickness and leishmaniasis. The results of the study pave the way to the development of more effective treatment.
In a longitudinal survey of children born in 2015 and 2016 in a city in Acre State, North Brazil, over half of the participants reported experiencing hunger in the previous month. The occurrence of symptoms also correlated with social vulnerability, and with the mother’s schooling and skin color.
Brazilian researchers have developed an algorithm to identify the protozoan Trypanosoma cruzi in photographs of blood samples taken with a mobile phone camera. The low-cost method is described in the journal PeerJ and can be reproduced.
Researchers at the University of São Paulo analyzed the expression of long non-coding RNAs, the type that does not give rise to proteins, in samples from patients and tumor cell lines, identifying a group of genes with augmented expression in pancreatic cancer.
The agreement was signed between the University of São Paulo, the state government and Pasteur Institute at an event held to celebrate the 200th anniversary of Louis Pasteur’s birth and FAPESP’s 60th anniversary. FAPESP renewed and expanded its support for the Scientific Platform Pasteur-USP, which will host the new research unit.
A clinical trial involving women aged 55-70 suggests that supplementing diet with this nutrient can reinforce the organism’s antioxidant defenses and possibly reduce the risk of cardiovascular disease, diabetes and high blood pressure. Studies with more volunteers are needed to confirm the effect.
Researchers at the State University of Campinas and the University of California San Diego have discovered the mechanism that causes this rare but severe autism spectrum disorder. They reversed progression of the syndrome in laboratory models, opening up new possibilities for treatment using drugs and gene therapy.
Brazilian researchers have discovered that PCNA, a protein present in the nuclei of human cells, interacts with the SARS-CoV-2 membrane matrix protein M. In laboratory tests, inhibition of this mechanism using a drug reduced viral replication by 15%-20%.
A startup supported by FAPESP has developed a technology based on artificial intelligence that can reduce the time to produce a diagnosis by 40%.
Several substances that killed antibiotic-resistant bacteria were found by Brazilian researchers in a marine sponge native to Fernando de Noronha, an archipelago off the coast of the Northeast.
Researchers at the University of São Paulo analyzed 43 scientific articles with data for some 11,500 athletes. The findings point to the need for carefully personalized assessment of athletes and sports players before a resumption of training is allowed, they warn.
Advanced drug discovery methods have led to advances in the search for treatments for some neglected tropical diseases, including leishmaniasis and Chagas, but research on schistosomiasis and other diseases caused by worms remains at an early stage, according to an article in Drug Discovery Today by Brazilian researchers.
Research that can increase Brazil’s access to CAR T-cell therapy, an increasingly important strategy for treating cancer, is under way at the University of São Paulo’s Center for Cell-Based Therapy (CTC) in Ribeirão Preto, and the Butantan Institute.
In mice fed a high-fat diet, the molecule mitigated weight gain while reducing insulin resistance and liver fattiness. An article describing the results of the study by researchers at the University of São Paulo and collaborators is published in the International Journal of Molecular Sciences.
Brazilian researchers surveyed 900 volunteers via an online platform for five months. Most reported feeling that time passed more slowly during home confinement in the early months of the pandemic, associating this perception with feelings of loneliness and a lack of positive experiences in the period.
The material can be used for diagnostic testing, research on the evolution of the monkeypox virus, and development of novel treatments and vaccines.
A protocol developed by the Brazil-UK Center for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology (CADDE) was used to analyze a sample from the first Brazilian patient with a confirmed diagnosis. The technology can also be used to detect unknown emerging viruses.
The finding comes from a clinical trial by researchers at the University of São Paulo who recruited 32 male volunteers and have now published the results in Clinical and Experimental Hypertension.
The approach combined nanotechnology, chemotherapy and monoclonal antibodies. It produced promising in vitro and in vivo results against glioblastoma multiforme.
Research reveals the mechanisms whereby methionine-deficient and methionine-supplemented diets can alter gene expression and damage liver cells.
A bioink developed from mouse cells can be used in a 3D printer to create a model that more closely resembles the brain than conventional ones. Researchers at the Federal University of São Paulo also obtained an adapted version of SARS-CoV-2 capable of infecting neural cells from mice.
