By combining acoustic levitation and X-ray diffraction with synchrotron light, the researchers were able to analyze the interactions of a drug’s atoms in real time and improve its formulation.
The finding by Brazilian researchers was based on data for 3,587 adolescents who took part in the US National Health and Nutrition Examination Survey (NHANES). Another finding of concern is a 63% higher risk of visceral obesity, which correlates closely with metabolic and cardiovascular diseases.
Results published in Scientific Reports by a research group at the Federal University of São Paulo help scientists understand why patients with metabolic syndrome are among those worst affected by COVID-19.
This was the main finding of a study by scientists affiliated with a FAPESP-supported research center. The effect may be associated with a mechanism whereby the fruit increases expression of an insulin-related microRNA.
In an editorial in the British Journal of Sports Medicine, Bruno Gualano, a professor at the University of São Paulo (Brazil), reviews what scientists know about the relationship between regular exercise and the disease caused by SARS-CoV-2.
A study shows how extracellular vesicles share information among cells in the same species, enabling the colony to respond in a coordinated manner to the host organism’s defenses.
Pythiosis affects humans, horses and other animals, often requiring surgery and even amputation. A study conducted at São Paulo State University has discovered seven potential antigens that can serve as a basis for tests and vaccines.
A study by researchers at the University of São Paulo advocates closer monitoring of these patients and prescribing more powerful drugs to combat atherosclerosis.
Scientists at a FAPESP-funded research center reprogrammed skin cells from patients with epilepsy to differentiate into cortical organoids with hallmarks of the malformation known as focal cortical dysplasia.
Whole-genome sequences of 1,171 elderly people living in São Paulo City were analyzed to detect mutations responsible for disease or that play a key role in healthy aging.
Brazilian researchers measured this increase in immunity in a study involving health workers who had received two doses of CoronaVac. In subjects given the Oxford-AstraZeneca vaccine, the same booster raised immunity by a factor of 7.
Triple-negative breast cancer grows rapidly and is highly likely to metastasize. Experiments with mice identified a molecule that binds to a defense cell receptor and activates an immune response against the tumor.
Researchers at São Paulo State University followed young men and women aged 20-40 without pre-existing disease. The findings show that obesity and physical inactivity increase the impact of the disease on the autonomic nervous system, which regulates blood pressure, heart rate and breathing, among other functions.
First-ever study to show correlation between inhibition of protein HSP70 and dysfunction of cells in inner lining of blood vessels, one of the factors involved in chronic thromboembolic pulmonary hypertension.
A study conducted in Brazil combined use of aerial photography and artificial intelligence to identify socio-economically deprived urban areas at risk for diseases transmitted by Aedes aegypti.
A group at the University of São Paulo has shown how metabolic alterations lead to a buildup of cholesterol in the cells of diabetic patients.
A multicenter research team investigated an outbreak in 2019, which proved to be due to a subtype of the pathogen that causes Newcastle disease. According to the researchers, the risk to humans and poultry is low.
Brazilian researchers conducted a randomized clinical trial to test the safety and efficacy of a 12-week home exercise program for 32 volunteers who had been hospitalized after contracting COVID-19.
Experiments in mice show for the first time that mutant mitochondrial DNA builds up during the final stage of egg formation. The discovery will serve as a basis for novel strategies to prevent transmission.
A system developed by a startup supported by FAPESP proves capable of predicting diabetic foot with over 85% accuracy. Foot complications occur in 34% of diabetics.
Brazilian researchers analyzed data for 2,777 patients hospitalized between January 5 and September 12, 2021. For those who had been fully vaccinated, being over 60 and having kidney failure were the sole predictors of hospitalization and death from COVID-19.
A study by researchers in Brazil and the UK reinforces the hypothesis that Drosophila melanogaster has a mutualistic relationship with Wolbachia bacteria. Their findings can help make the fight against mosquito-borne diseases more effective.
Experiments were conducted on mice by a group at the University of São Paulo. The results, reported in the journal Endocrinology, could have future implications for therapies to control body weight.
Patients submitted to a procedure that “resets” the immune system were tracked for a year by scientists at a FAPESP-supported research center. Their clinical improvement correlated with renewal of a group of defense cells known as B lymphocytes.
Brazilian researchers tracked 425 patients for six to nine months after hospital discharge. Over half reported memory decline, and tests showed significant cognitive impairments in the group.
