Pythiosis affects humans, horses and other animals, often requiring surgery and even amputation. A study conducted at São Paulo State University has discovered seven potential antigens that can serve as a basis for tests and vaccines.
A study by researchers at the University of São Paulo advocates closer monitoring of these patients and prescribing more powerful drugs to combat atherosclerosis.
Scientists at a FAPESP-funded research center reprogrammed skin cells from patients with epilepsy to differentiate into cortical organoids with hallmarks of the malformation known as focal cortical dysplasia.
Whole-genome sequences of 1,171 elderly people living in São Paulo City were analyzed to detect mutations responsible for disease or that play a key role in healthy aging.
Brazilian researchers measured this increase in immunity in a study involving health workers who had received two doses of CoronaVac. In subjects given the Oxford-AstraZeneca vaccine, the same booster raised immunity by a factor of 7.
Triple-negative breast cancer grows rapidly and is highly likely to metastasize. Experiments with mice identified a molecule that binds to a defense cell receptor and activates an immune response against the tumor.
Researchers at São Paulo State University followed young men and women aged 20-40 without pre-existing disease. The findings show that obesity and physical inactivity increase the impact of the disease on the autonomic nervous system, which regulates blood pressure, heart rate and breathing, among other functions.
First-ever study to show correlation between inhibition of protein HSP70 and dysfunction of cells in inner lining of blood vessels, one of the factors involved in chronic thromboembolic pulmonary hypertension.
A study conducted in Brazil combined use of aerial photography and artificial intelligence to identify socio-economically deprived urban areas at risk for diseases transmitted by Aedes aegypti.
A group at the University of São Paulo has shown how metabolic alterations lead to a buildup of cholesterol in the cells of diabetic patients.
A multicenter research team investigated an outbreak in 2019, which proved to be due to a subtype of the pathogen that causes Newcastle disease. According to the researchers, the risk to humans and poultry is low.
Brazilian researchers conducted a randomized clinical trial to test the safety and efficacy of a 12-week home exercise program for 32 volunteers who had been hospitalized after contracting COVID-19.
Experiments in mice show for the first time that mutant mitochondrial DNA builds up during the final stage of egg formation. The discovery will serve as a basis for novel strategies to prevent transmission.
A system developed by a startup supported by FAPESP proves capable of predicting diabetic foot with over 85% accuracy. Foot complications occur in 34% of diabetics.
Brazilian researchers analyzed data for 2,777 patients hospitalized between January 5 and September 12, 2021. For those who had been fully vaccinated, being over 60 and having kidney failure were the sole predictors of hospitalization and death from COVID-19.
A study by researchers in Brazil and the UK reinforces the hypothesis that Drosophila melanogaster has a mutualistic relationship with Wolbachia bacteria. Their findings can help make the fight against mosquito-borne diseases more effective.
Experiments were conducted on mice by a group at the University of São Paulo. The results, reported in the journal Endocrinology, could have future implications for therapies to control body weight.
Patients submitted to a procedure that “resets” the immune system were tracked for a year by scientists at a FAPESP-supported research center. Their clinical improvement correlated with renewal of a group of defense cells known as B lymphocytes.
Brazilian researchers tracked 425 patients for six to nine months after hospital discharge. Over half reported memory decline, and tests showed significant cognitive impairments in the group.
A group at São Paulo State University (UNESP) is working on pharmacological strategies to block sperm motility.
Although this variant of SARS-CoV-2 is less aggressive, the explosive growth of case numbers has again driven health services to the verge of collapse. Lack of tests and a “data blackout” at the Health Ministry make an accurate assessment of the situation impossible.
An article in the Journal of Medical Virology by researchers affiliated with the Federal University of São Paulo in Brazil argues that this is the reason for the relatively small proportion of severe cases and deaths among vaccinated patients despite omicron’s greatly increased transmissibility.
The wearable device has screen-printed sensors on three fingers to detect the presence of toxic substances in fruit and vegetables. Prior preparation of samples is not required, and no waste is generated.
The clinical trial involved 44 volunteers with advanced bladder cancer. The award of a US patent should facilitate cooperation between the researchers and the pharmaceutical industry to proceed to the next stage of drug development.
The technique is used for in vitro studies of the behavior of astrocytes in a three-dimensional format, and can be adapted for neurons and other cell types. The model has been used to investigate the effects of COVID-19 on the central nervous system.
