In experiments by Brazilian researchers with mice and tumor cell lines, the drug showed potential to combat metastasis. The scientists are planning to conduct clinical trials with patients who are on chemotherapy.
An in vitro study by a Brazilian researcher shows that maresin and resolvin synthesized from fatty acid stimulate periodontal ligament stem cells even in the presence of inflammation.
A study performed at one of the Research Centers supported by FAPESP resulted in development of a novel rehabilitation device. The article was recognized as outstanding by the 20th International Conference on Computational Science and its Applications.
Brazilian researchers show that commercial serological tests available in laboratories nationwide can be used to screen donated plasma in order to see if it contains enough antibodies capable of neutralizing the novel coronavirus
In an article published in the Journal of Pineal Research, researchers at São Paulo State University and collaborators describe a set of genes potentially regulated by the “sleep hormone” in some types of tumor
In vitro studies and experiments with mice show that the natural extract was more effective than the only drug available to combat this parasitic disease.
Experiments with mice and humans showed that exercise training increased the expression in adipose tissue of a key enzyme for the organism’s metabolic health, combating the harmful effects of aging and obesity.
Medication originally developed to kill bacteria displayed the capacity to increase cell energy expenditure in tests with mice. Researchers at the University of Campinas and the biopharmaceutical AstraZeneca are testing compounds with a similar structure that could give rise to novel approaches to the treatment of obesity.
In defense cells from patients hospitalized with the disease, Brazilian researchers found signs of activation of a protein complex called the inflammasome, responsible for initiating the inflammatory response that can damage organs and lead to death. The findings could help identify drugs capable of interrupting the process.
An article in Cell by researchers affiliated with Harvard and the University of São Paulo shows that the metabolite succinate is released by muscle cells during physical exercise and triggers a process of tissue remodeling that makes muscles stronger and enhances metabolic efficiency.
Food engineers in Brazil and France developed gels based on modified starch for use as “ink” to make foods and novel materials by additive manufacturing.
The special series “Field Diary” (“Diário de Campo”) features University of São Paulo scientists Marcelo Urbano Ferreira and Marly Augusto Cardoso on an expedition to Mâncio Lima, a small town in the Amazon where they collect samples from patients to investigate transmission of the novel coronavirus.
Genetic mapping of the shark’s liver and eye tissue showed overexpression of nine genes known for action in tumor suppression, wound healing, and probable monochrome vision. The species is considered globally endangered and caught on a large scale by industrial fishing vessels.
With FAPESP’s support, the Nuclear and Energy Research Institute is assembling a world-class laboratory that associates nanotechnology with radiopharmacy. The aim is to develop new products, mainly for cancer treatment.
Researchers at the University of São Paulo identified proteins found at augmented levels in the blood plasma of high-risk patients using equipment present in Brazilian hospitals. The result of the test could help physicians make better-targeted decisions.
Analysis of DNA from 1,171 over-sixties living in São Paulo will enable scientists to identify genetic mutations responsible for diseases or important to healthy aging, according to the authors of the study.
In laboratory tests, the material eliminated 79.9% of SARS-CoV-2 particles in three minutes and 99.99% in up to 15 minutes.
Preliminary results of patient tissue analysis show that the virus infects adipocytes and alters the quantity of signaling molecules released by these cells into the bloodstream.
Scientists at a research center supported by FAPESP identified a non-inherited mutation in blood cells from a patient with GATA2 deficiency that may have prevented bone marrow failure and other clinical manifestations.
Research shows how Nef subverts human cells’ defense mechanisms to enable HIV to advance; Brazilian scientists comment on progress in this area in Nature group journal article.
Monoclonal antibody tested by researchers at University of São Paulo and experimental drug given to patients in Italy by University of Pennsylvania research group promoted rapid improvement of respiratory function in patients hospitalized in severe condition.
Researchers examine retinas and find high prevalence of type 2 diabetes as well as ocular problems caused by the disease.
Brazilian researchers discovered that sTREM-1 protein in immunoglobulin family could be a very useful biomarker to help medical teams make clinical decisions.
Sirius’s protein crystallography beamline analyzed more than 200 protein crystals from the novel coronavirus as they were exposed to tiny fragments of widely used drugs. If a compound fits perfectly into a target protein, its action can be blocked in the virus.
Devices developed by Brazilian startup BioLambda decontaminate face shields, surfaces, workspaces and air.
