By means of specific biomarkers, a diagnostic test developed by the Brazilian startup Onkos shows whether a lump in the gland is benign or malignant, reducing the risk of unnecessary surgery.
The platform developed by researchers from Brazil and Chile lets users view geolocation of cases, deaths and vaccinations over time.
A study by the University of São Paulo has discovered that when macrophages engulf cells infected by the novel coronavirus, they begin producing excessive amounts of pro-inflammatory molecules, and their capacity to recognize and phagocytize dead cells is reduced twelvefold.
Brazilian researchers monitoring the population of metropolitan São Paulo have reported atypical cases in which SARS-CoV-2 continues to replicate in the organism for longer than the recommended isolation period.
A method created in Brazil by the Human Genome and Stem Cell Research Center could be used for large-scale production of livers for transplantation.
Extracorporeal membrane oxygenation (ECMO) can keep patients alive until the disease recedes.
Brazilian researchers treated cells infected by SARS-CoV-2 with compounds produced by gut microbiota from dietary fiber. The intervention did not mitigate viral replication but reduced expression of a gene that plays a key role in viral entry into cells and a receptor involved in the inflammatory process.
Luciferin-luciferase system developed in collaboration with Japanese researchers produces brighter and longer-lasting far red light. The innovation can be used to image cells and tissues for diagnosis and biomedical research.
Laboratory trial by Butantan Institute in partnership with the University of São Paulo involved inoculation of variants P.1 and P.2 into cultured cells containing blood serum from vaccinated subjects. The results were satisfactory, according to the researchers.
The technology uses ultraviolet-C, which can inactivate the novel coronavirus. Startup BioLambda was supported by FAPESP and partnered with the Albert Einstein Jewish-Brazilian Hospital in São Paulo.
Brazilian researchers tested the capacity of different materials to produce sensors for the detection of PCA3, a gene that is overexpressed in prostate cancer. The technique can also be used to diagnose infectious diseases, including COVID-19.
In a study of the effects of cigarette smoking on exacerbation of the disease, scientists at a FAPESP-supported research center identified a novel pathway in the inflammatory process relating to bone damage.
In Araraquara, state of São Paulo, researchers detected the P.1 variant in 93% of samples from patients diagnosed at a primary healthcare facility in the first two months of the year.
Blood plasma from COVID-19 convalescents was tested against Brazilian variant isolates obtained from patients diagnosed in Manaus. The study also assessed the effectiveness of plasma from volunteers immunized with CoronaVac.
Published by an Anglo-Brazilian epidemiological research center, the study revealed that in only seven weeks SARS-CoV-2 lineage P.1 became the most prevalent strain of the virus in Manaus. Analysis of more than 900 samples from patients diagnosed in the period pointed to a higher viral load.
In a study conducted at the University of São Paulo, researchers used infrared laser irradiation to accelerate the activity of enzymes immobilized on gold nanoparticles. The technique could have biomedical and industrial applications.
Open-access repository established to facilitate research on the disease holds anonymized data including clinical examinations and laboratory test results from 485,000 patients processed by five institutions.
Study conducted at a FAPESP-supported research center shows that anti-inflammatory peptide TnP could lead to drug development.
Study suggests that replacing native vegetation with pasture or crops increases competition among microorganisms, favoring those with antimicrobial resistance genes. Brazilian scientists advocate more research to find out whether bacteria can migrate to food and reach humans.
In October the CDC recommended ten instead of 14 days of isolation for patients with mild or moderate symptoms, but Brazilian researchers found viable viral particles in 25% of samples collected from patients on the tenth day of symptoms.
The use of CAR T-cells reprogrammed to “recognize” Cryptococcus spp. proved effective to combat the infection in vitro and in mice.
Scientists will monitor areas in which these diseases are endemic, such as São Paulo, the Amazon, the Pantanal and Panama, to investigate the factors that trigger outbreaks.
According to a paper by Brazilian researchers published in Nano Today, the spatial arrangement of proteins on the surface of SARS-CoV-2 assures highly efficient interaction with target receptors on human cells.
The different criteria used in Phase 3 clinical trials of the vaccines approved so far were explained by scientists in a webinar hosted by FAPESP. The impact of delays in vaccinating Brazilians was one of the topics discussed.
An analysis conducted in the Brazilian state of São Paulo detected seven proteins in plasma from hospitalized patients that could be used in novel treatments and methods of identifying potentially severe or critical cases.
