Brazilian and French researchers have studied specimens of the vector insect captured in Brazil that recorded an outbreak of the disease and have observed a high prevalence of infection by T. cruzi; two species of rodents were identified as potential reservoirs of the parasite
A study conducted in Brazil shows that Stenotrophomonas maltophilia, a common drug-resistant pathogen in hospitals, kills rival bacteria with a cocktail of toxins. This discovery could lead to the development of new antibiotics.
In a lecture given at FAPESP Week France, Brazilian scientist Francisco Fraga da Silva spoke about developing a low-cost diagnostic alternative based on electroencephalography data.
A Brazilian team at FAPESP-supported Center for Research on Inflammatory Diseases identified the strategy used by immune cells to combat the pathogen Mayaro virus, which causes symptoms similar to those of chikungunya fever. These results pave the way for the development of drugs.
Therapy used against grade four glioblastoma multiforme combines a photoactive molecule and a chemotherapeutic agent – both encapsulated in protein-lipid nanoparticles; work was presented by Antônio Claudio Tedesco during FAPESP Week France.
Intestinal microbiota of mosquito that transmits dengue and of bugs resistant to insecticides is the focus of studies developed at the Université Claude Bernard Lyon 1 and presented at FAPESP Week France.
Research that will be presented today at FAPESP Week France suggests that bacteria present in the intestine of the Anhopheles darlingi mosquito influence the development of the parasite that causes the disease in the insect’s body and the chances of transmission to humans.
Product developed with FAPESP’s support has been licensed by Brazil’s public health surveillance agency after trials involving more than 3,000 women. The method can detect old infections, even in patients who have had dengue or yellow fever.
An experiment in rats performed in Brazil shows that this “wellbeing hormone” helps modulate the immune system, induces anti-inflammatory effects, and prevents complications such as a sharp drop in body temperature and blood pressure.
With support from FAPESP, BiDiagnostics plans to develop a methodology to detect the most prevalent and virulent species of the fungus that causes sporotrichosis. The number of notified cases in Brazil has increased 600% in the past five years.
A study by Brazilian researchers suggests that cardiac overload due to the stress of driving in heavy traffic can be attenuated by listening to instrumental music.
A microRNA inhibitor identified by researchers at the FAPESP-supported Human Genome and Stem Cell Research Center reduced the sizes of aggressive tumors and improved survival in mice.
Researchers in Brazil altered the chemical structure of alkaloids from cat’s claw, aiming to obtain more potent compounds for the treatment of tumors and inflammations; scientists plan to develop a modified strain of U. guianensis and use its own metabolism to scale up the production of therapeutic compounds.
Systems that assess and train decision-making skills have been developed by a startup supported by FAPESP and tested on athletes belonging to top-tier Brazilian sports clubs. The researchers responsible say the technology can also be used in sectors such as healthcare.
Tests in rats showed enhanced efficacy of the drug as well as the absence of side effects, such as stomach bleeding. This innovation could be used to treat temporomandibular joint inflammation.
Patient with advanced refractory lymphoma was treated in Brazil by researchers at a center funded by FAPESP. The technique known as CAR T-cell therapy was used for first time ever in Latin America.
Researchers tested a material known as polyether siloxane, a flexible transparent hydrogel that can absorb large amounts of water without dissolving and is ideal for controlled-release drug delivery.
Scientists show that CRP3, normally produced in arteries, is expressed in saphenous vein grafts following coronary artery bypass surgery. The finding suggests that this molecule participates in adaptation to the increased blood flow and pressure resulting from arterialization.
Experiments using human brain cells and mice suggest that lithium delays cellular aging, one of the factors in neurodegenerative disorders.
Phylogenomic analysis shows that pathogen isolated in Brazilian hospital does not belong to the genus Leishmania. Researchers are investigating whether this species alone can cause severe disease or intensifies symptoms in co-infected patients.
Researchers at a Research, Innovation and Dissemination Center supported by FAPESP have created a composite with antifungal properties that are 32 times greater than those of silver by irradiating a metallic tungstate with electrons and femtosecond laser light.
Blood sugar levels in obese mice were controlled more efficiently when the mice were challenged with a glucose overload and treated with 12-HEPE, a lipid produced in response to cold by brown adipose tissue.
Compound inhibits key enzymes, interrupting the parasite’s lifecycle in human organisms and preventing transmission to vector insects. This discovery published in Science involved researchers funded by FAPESP.
Four substances isolated from Mimosa caesalpiniifolia were found to be more effective against thrush and candida than was fluconazole, the drug usually prescribed to treat the disease. Brazilian researchers are developing an ointment.
Using a systems biology approach, Brazilian researchers identified several genes that can be explored as therapeutic targets and as biomarkers of predisposition to chronic joint pain.
