Blood sugar levels in obese mice were controlled more efficiently when the mice were challenged with a glucose overload and treated with 12-HEPE, a lipid produced in response to cold by brown adipose tissue.
Compound inhibits key enzymes, interrupting the parasite’s lifecycle in human organisms and preventing transmission to vector insects. This discovery published in Science involved researchers funded by FAPESP.
Four substances isolated from Mimosa caesalpiniifolia were found to be more effective against thrush and candida than was fluconazole, the drug usually prescribed to treat the disease. Brazilian researchers are developing an ointment.
Using a systems biology approach, Brazilian researchers identified several genes that can be explored as therapeutic targets and as biomarkers of predisposition to chronic joint pain.
Genetic profiles of microorganisms isolated from patients with urinary tract infection display a high degree of resistance and virulence. The superbug KPC was found in samples.
A study by researchers at the Center for Cell-Based Therapy, which is supported by FAPESP, identified microRNAs involved in pluripotency maintenance and cell differentiation. The discovery paves the way to the development of drugs capable of making ESCs regress to the earliest stage of development.
In a study supported by FAPESP, experiments with mice showed the anti-inflammatory drug mefenamic acid to be more efficacious than praziquantel, the only drug available to combat the disease.
Study conducted to test a procedure based on ionization of atmospheric air eliminates 99% of Candida albicans fungus that causes hospital-acquired infections, without generating toxic waste.
Vanderlei Martins, a professor at the University of Maryland and former FAPESP grantee, is responsible for the device, developed in partnership with NASA. Martins spoke about the project to the São Paulo School of Advanced Science on Atmospheric Aerosols, which was funded by FAPESP.
Brazilian researchers observed the association only in subjects who consumed more than three small cups of coffee per day. Moderate consumption, however, appears to have beneficial effects on the cardiovascular system.
A FAPESP-funded study with results published in The Lancet Infectious Diseases has identified markers capable of predicting mortality in patients with symptoms of yellow fever, potentially helping to prevent the development of severe conditions.
The results of a clinical trial published in the journal Appetite show that transcranial direct current stimulation can reduce or increase appetite, depending on the patient’s genetic profile.
A system created in Brazil using cheap, biodegradable materials permits controlled release of larvicide and can be used in small amounts of water.
Method developed by Brazilian and US researchers distinguishes between malignant and benign tumors and rules out false positive results.
Experiments with mice performed within the scope of a FAPESP-funded study show that a substance derived from cannabis plants attenuates isolation-induced aggressive behavior.
A study of individuals over 65 years old showed that all-cause mortality risk increased nearly 63-fold in women with low appendicular muscle mass. The risk of dying increased 11.4-fold in men.
Developed by Brazilian researchers, the biosensor identifies the presence of different pathogens more quickly and cheaply than standard methods.
Data recorded via smartphone are stored in the cloud to help diagnose sleep apnea.
A FAPESP-funded study investigated behaviors associated with weight gain and cardiometabolic risk in adolescents. Missing the first meal of the day can contribute to the development of unhealthy habits and behaviors.
French researchers made the discovery by analyzing blood from denim sandblasters. The results were presented at the Inflamma symposium organized by the Center for Research on Inflammatory Diseases in Brazil.
Simplified low-cost method is as accurate as most advanced sequencers in analyzing medulloblastoma, enabling personalized treatment to be prescribed in developing countries.
Researchers find that substances synthesized from plant species endemic to the biodiversity hotspot can kill the parasites that cause these neglected diseases.
X-ray imaging shows that nanostructured silica acts as protective vehicle to deliver antigen intact to intestine so that it can trigger an immune response. Material developed with FAPESP funding could give rise to polyvaccine against six diseases.
Enzyme found in pineapple stems stimulates the gut to produce enkephalin, an opioid peptide normally released by the brain.
Technique developed in Brazil uses infrared light to release photoactive material and cancer drug inside tumor cells and kill them with hyperthermia.
