A microRNA inhibitor identified by researchers at the FAPESP-supported Human Genome and Stem Cell Research Center reduced the sizes of aggressive tumors and improved survival in mice.
Researchers in Brazil altered the chemical structure of alkaloids from cat’s claw, aiming to obtain more potent compounds for the treatment of tumors and inflammations; scientists plan to develop a modified strain of U. guianensis and use its own metabolism to scale up the production of therapeutic compounds.
Systems that assess and train decision-making skills have been developed by a startup supported by FAPESP and tested on athletes belonging to top-tier Brazilian sports clubs. The researchers responsible say the technology can also be used in sectors such as healthcare.
Tests in rats showed enhanced efficacy of the drug as well as the absence of side effects, such as stomach bleeding. This innovation could be used to treat temporomandibular joint inflammation.
Patient with advanced refractory lymphoma was treated in Brazil by researchers at a center funded by FAPESP. The technique known as CAR T-cell therapy was used for first time ever in Latin America.
Researchers tested a material known as polyether siloxane, a flexible transparent hydrogel that can absorb large amounts of water without dissolving and is ideal for controlled-release drug delivery.
Scientists show that CRP3, normally produced in arteries, is expressed in saphenous vein grafts following coronary artery bypass surgery. The finding suggests that this molecule participates in adaptation to the increased blood flow and pressure resulting from arterialization.
Experiments using human brain cells and mice suggest that lithium delays cellular aging, one of the factors in neurodegenerative disorders.
Phylogenomic analysis shows that pathogen isolated in Brazilian hospital does not belong to the genus Leishmania. Researchers are investigating whether this species alone can cause severe disease or intensifies symptoms in co-infected patients.
Researchers at a Research, Innovation and Dissemination Center supported by FAPESP have created a composite with antifungal properties that are 32 times greater than those of silver by irradiating a metallic tungstate with electrons and femtosecond laser light.
Blood sugar levels in obese mice were controlled more efficiently when the mice were challenged with a glucose overload and treated with 12-HEPE, a lipid produced in response to cold by brown adipose tissue.
Compound inhibits key enzymes, interrupting the parasite’s lifecycle in human organisms and preventing transmission to vector insects. This discovery published in Science involved researchers funded by FAPESP.
Four substances isolated from Mimosa caesalpiniifolia were found to be more effective against thrush and candida than was fluconazole, the drug usually prescribed to treat the disease. Brazilian researchers are developing an ointment.
Using a systems biology approach, Brazilian researchers identified several genes that can be explored as therapeutic targets and as biomarkers of predisposition to chronic joint pain.
Genetic profiles of microorganisms isolated from patients with urinary tract infection display a high degree of resistance and virulence. The superbug KPC was found in samples.
A study by researchers at the Center for Cell-Based Therapy, which is supported by FAPESP, identified microRNAs involved in pluripotency maintenance and cell differentiation. The discovery paves the way to the development of drugs capable of making ESCs regress to the earliest stage of development.
In a study supported by FAPESP, experiments with mice showed the anti-inflammatory drug mefenamic acid to be more efficacious than praziquantel, the only drug available to combat the disease.
Study conducted to test a procedure based on ionization of atmospheric air eliminates 99% of Candida albicans fungus that causes hospital-acquired infections, without generating toxic waste.
Vanderlei Martins, a professor at the University of Maryland and former FAPESP grantee, is responsible for the device, developed in partnership with NASA. Martins spoke about the project to the São Paulo School of Advanced Science on Atmospheric Aerosols, which was funded by FAPESP.
Brazilian researchers observed the association only in subjects who consumed more than three small cups of coffee per day. Moderate consumption, however, appears to have beneficial effects on the cardiovascular system.
A FAPESP-funded study with results published in The Lancet Infectious Diseases has identified markers capable of predicting mortality in patients with symptoms of yellow fever, potentially helping to prevent the development of severe conditions.
The results of a clinical trial published in the journal Appetite show that transcranial direct current stimulation can reduce or increase appetite, depending on the patient’s genetic profile.
A system created in Brazil using cheap, biodegradable materials permits controlled release of larvicide and can be used in small amounts of water.
Method developed by Brazilian and US researchers distinguishes between malignant and benign tumors and rules out false positive results.
Experiments with mice performed within the scope of a FAPESP-funded study show that a substance derived from cannabis plants attenuates isolation-induced aggressive behavior.
