Groundbreaking study shows that regular exercise in prepubertal childhood improves the functioning of cells essential to vascular health. Babies weighing less than 2.5 kg at birth are more likely to develop cardiovascular diseases in adulthood.
Species never before found in humans described in PLOS ONE belong to the genera Ambidensovirus and Chapparvovirus. Researchers do not yet know if they can cause disease.
Scientists at Brazil’s National Energy and Materials Research Center are analyzing the antiviral action of commercially available drugs in cultured cells.
Researchers explains how their experience with the Zika virus, made possible with funding from FAPESP, helped them to cultured the SARS-CoV-2 coronavirus.
Scientists in the state of São Paulo are working on a method of diagnosing the disease quickly and cheaply by combining an analysis of the pattern of molecules in body fluids with machine learning.
A population study conducted at a regional center of the state of São Paulo (Brazil) showed that 32.9% of subjects under 40 had no immunity against the disease, compared with only 1% in those over 50.
The blood test method makes use of machine learning and can be used to predict whether patients will put on weight, unless they change their habits. The project was conducted in Brazil with funding from FAPESP.
Experiments with rats indicate that brain cells submitted to several forms of hypoxia underwent alterations to their energy production mechanism. Such condition may affect the fetus in pregnant women who have developed pre-eclampsia, a high blood pressure disorder.
A discovery by scientists affiliated with a research center supported by FAPESP could contribute to the development of more powerful photosensitizers. When these molecules are exposed to light, they trigger biochemical processes that lead to the disruption of the cell membranes of tumors or pathogens.
Brazilian researchers found the level of uric acid in saliva to be a good indicator of body fat percentage. Study was designed to identify reliable biomarkers that can be used to develop quick noninvasive tests for early detection of chronic diseases.
This topic was discussed by specialists from several countries at the São Paulo School of Advanced Science on Mental Health and Evidence-Based Interventions, an event held with the support of FAPESP.
Researchers at Butantan Institute succeeded in reducing the toxicity and potentiating the analgesic effect of crotoxin by encapsulating it in nanostructured silica. The results of tests in an animal model of neuropathic pain, one of the hardest kinds of pain to treat, are promising.
The technique can contribute to a deeper understanding of neurodegenerative diseases and lead to applications in drug testing. In the future, this technique could be used to reconstruct damaged parts of the brain.
The device was developed by Brazilian scientists using nontoxic, biodegradable, low-cost materials. It can be used by people with diabetes to monitor blood sugar.
Researchers at Paris Diderot University in France propose the use of vesicles secreted by adipose stem cells as a biological therapeutic system. The methodology has been successfully tested in pigs.
Compounds based on palladium, a metal belonging to the same group as platinum, have been developed by researchers from Brazil, the UK and Italy. In vitro tests show action against tumor cells that are resistant to treatment currently used in clinical practice.
Researchers describe two pre-programmed strategies used by the human organism to combat infection: resistance to pathogens by means of fever; and temporary tolerance promoted by controlled hypothermia. A combination of these two mechanisms could afford an alternative approach to studying and treating severe conditions such as sepsis.
Partnering with scientists at Harvard, a group of Brazilians affiliated with the Center for Research on Inflammatory Diseases (CRID), supported by FAPESP, described the mechanisms that cause hair color loss in extreme situations.
Falling investment in health promotion policies is one of the obstacles to the prevention of HIV-AIDS.
Experiments performed by Brazilian scientists showed that Zika virus inhibits tumor cell proliferation even when inactivated by high temperature. The study was supported by FAPESP and published in Scientific Reports.
A Brazilian research group tested the effects of different chemical groups added to the surface of nanoparticles with the aim of making them ‘invisible’ to the immune system, safe for human cells, and effective against pathogens and tumors.
The meeting was organized by the Consulate General of the Kingdom of the Netherlands in São Paulo and FAPESP with the aim of fostering collaborative research.
Researchers in Brazil evaluated cocaine and crack addicts undergoing rehabilitation for six months and observed a higher relapse rate and worse cognitive impairment among patients who smoked cannabis to try to mitigate their craving for cocaine.
Researchers have revealed the molecular mechanisms that make the Brazilian strain of Shiga toxin-producing E. coli less virulent and pathogenic than strains of the bacterium found in other countries. Their findings can be used to formulate epidemiological surveillance strategies.
The FAPESP-funded Center for Cell-Based Therapy explored the action mechanism of a microRNA that reduces tumor size and blocks metastasis when overexpressed.
