A study shows that administering coenzyme Q10 reverses damage done to germinative cells by BPA, a contaminant found in many kinds of plastic.
To develop a drug capable of treating the disease caused by the novel coronavirus, a research institution in São Paulo will deploy a platform used to produce monoclonal antibodies against tetanus and zika.
Brazilian researchers show that the activity of the gene TRIB3 in lung cells declines in men as they age. Compounds capable of reversing the process could be tested against the novel coronavirus.
Selected projects aim to repurpose existing drugs for treatment of COVID-19, find novel compounds with therapeutic potential and develop alternative diagnostic methods. The call remains open until June 22.
AI-based technology developed by a São Paulo startup supported by FAPESP is in use at Albert Einstein Jewish Hospital to reduce the risk of coronavirus transmission
Electrical impedance tomography system developed by startup based in São Paulo minimizes complications associated with mechanical ventilation and is used in the treatment of COVID-19 by hospitals in Italy, Spain and the US.
Scientists affiliated with the FAPESP-funded Center for Cell-Based Therapy have collected plasma from donors and are conducting a trial to check the safety and effectiveness of passive immunization.
Researchers at the University of Campinas are organizing professionals, supplies and equipment to test for COVID-19, understand how the virus works, identify existing drugs that are effective against the disease, and use 3D printing to produce parts for ventilators and personal protective equipment.
Based in São Paulo, Magnamed will produce 6,500 ventilators by August for use in treating COVID-19 patients, working in partnership with a pool of leading Brazilian and multinational corporations.
Diagnostic strategy developed by Brazilian researchers can also be used to distinguish MS from neuromyelitis optica, another demyelinating disorder. The two diseases have similar symptoms but must be treated differently.
Brazilian researchers use minimally invasive technique to perform autopsies on deceased patients diagnosed with COVID-19, with the aim of assisting physicians and other health workers.
Research by the FAPESP-funded Center for Metropolitan Studies (CEM) shows that it is not feasible to separate high-risk groups in low-income communities, where the majority of the Brazilian population live. The problem is especially acute in the Southeast region, with metropolitan São Paulo displaying the largest deficit.
Metabolic changes associated with diseases such as pulmonary hypertension and chronic obstructive pulmonary disease may reprogram gene expression to increase production of a protein used by SARS-CoV-2 to penetrate lung cells.
Groundbreaking study shows that regular exercise in prepubertal childhood improves the functioning of cells essential to vascular health. Babies weighing less than 2.5 kg at birth are more likely to develop cardiovascular diseases in adulthood.
Species never before found in humans described in PLOS ONE belong to the genera Ambidensovirus and Chapparvovirus. Researchers do not yet know if they can cause disease.
Scientists at Brazil’s National Energy and Materials Research Center are analyzing the antiviral action of commercially available drugs in cultured cells.
Researchers explains how their experience with the Zika virus, made possible with funding from FAPESP, helped them to cultured the SARS-CoV-2 coronavirus.
Scientists in the state of São Paulo are working on a method of diagnosing the disease quickly and cheaply by combining an analysis of the pattern of molecules in body fluids with machine learning.
A population study conducted at a regional center of the state of São Paulo (Brazil) showed that 32.9% of subjects under 40 had no immunity against the disease, compared with only 1% in those over 50.
The blood test method makes use of machine learning and can be used to predict whether patients will put on weight, unless they change their habits. The project was conducted in Brazil with funding from FAPESP.
Experiments with rats indicate that brain cells submitted to several forms of hypoxia underwent alterations to their energy production mechanism. Such condition may affect the fetus in pregnant women who have developed pre-eclampsia, a high blood pressure disorder.
A discovery by scientists affiliated with a research center supported by FAPESP could contribute to the development of more powerful photosensitizers. When these molecules are exposed to light, they trigger biochemical processes that lead to the disruption of the cell membranes of tumors or pathogens.
Brazilian researchers found the level of uric acid in saliva to be a good indicator of body fat percentage. Study was designed to identify reliable biomarkers that can be used to develop quick noninvasive tests for early detection of chronic diseases.
This topic was discussed by specialists from several countries at the São Paulo School of Advanced Science on Mental Health and Evidence-Based Interventions, an event held with the support of FAPESP.
Researchers at Butantan Institute succeeded in reducing the toxicity and potentiating the analgesic effect of crotoxin by encapsulating it in nanostructured silica. The results of tests in an animal model of neuropathic pain, one of the hardest kinds of pain to treat, are promising.
