A protocol developed by the Brazil-UK Center for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology (CADDE) was used to analyze a sample from the first Brazilian patient with a confirmed diagnosis. The technology can also be used to detect unknown emerging viruses.
The finding comes from a clinical trial by researchers at the University of São Paulo who recruited 32 male volunteers and have now published the results in Clinical and Experimental Hypertension.
The approach combined nanotechnology, chemotherapy and monoclonal antibodies. It produced promising in vitro and in vivo results against glioblastoma multiforme.
Research reveals the mechanisms whereby methionine-deficient and methionine-supplemented diets can alter gene expression and damage liver cells.
A bioink developed from mouse cells can be used in a 3D printer to create a model that more closely resembles the brain than conventional ones. Researchers at the Federal University of São Paulo also obtained an adapted version of SARS-CoV-2 capable of infecting neural cells from mice.
Researchers at the University of São Paulo analyzed data for a group of pregnant women in western Amazonia. The analysis pointed to a correlation between at least 150 minutes of physical activity per week and lower birth weight, with less risk of childhood obesity and diabetes.
The results of a clinical trial are reported by Brazilian researchers in Frontiers in Cardiovascular Medicine. According to the authors, if corroborated by more robust research, the findings indicate that the method can be used in emergency treatment of hypertensive crisis patients.
Mathematic simulations showed that well-executed non-pharmacological measures reduce the spread of COVID-19 even in places with low vaccination coverage. According to the authors, however, up to 80% of the population could catch the disease if preventive protocols are abandoned.
The open-access platform developed by researchers at the University of São Paulo offers access to strategic information on microorganisms classified by WHO as a “critical priority”. The aim is to contribute to the monitoring and control of bacteria that pose a great threat to human and animal health.
With aging, mutant genetic material tends to build up in the organelles responsible for producing energy, and this can lead to disease. Brazilian researchers have discovered that a cell cleansing mechanism known as autophagy can modulate this phenomenon.
Experiments involving isolated and cultured cells as well as animals and babies suggest that short-chain fatty acid acetate produced in the gut can minimize the effects of infection by respiratory syncytial virus.
Devices that combine laser irradiation, ultrasound and suction help regenerate tissue and treat muscle, joint, skin, neurological and lung damage. Protocols created via business-university partnerships are being tested and can be applied by treatment centers across Brazil.
An article in Scientific Reports shows that experimental treatment with a protein-derived molecule reduced tumor growth and metastasis, increasing the survival of mice by 25%.
The discovery is reported by researchers at Harvard University and the University of São Paulo in Nature Neuroscience, and could serve as a basis for the development of treatments for different diseases.
Scientists at a consortium of Brazilian universities show how the enzyme storm triggered by SARS-CoV-2 damages the lungs and may cause lasting complications.
Researchers affiliated with the University of São Paulo’s Medical School compared immune cells from COPD patients, healthy young and old adults, and smokers. The finding helps explain why these patients respond poorly to vaccines and are more susceptible to infections.
The computational platform developed by the firm, with FAPESP’s support, is capable of screening billions of molecules.
This was the conclusion reached by a study conducted in Brazil that analyzed data for 3,875 elderly men and women collected over an eight-year period. An article on the study is published in The American Journal of Clinical Nutrition.
Conducted by an international group that included Brazilian scientists, the project created charts that show how the brain grows rapidly in early life and shrinks as we age. The researchers hope the charts will one day be used in clinical practice.
An article published in Nature by a consortium of researchers from 45 countries, including Brazil, reports on a study that analyzed data for 300,000 people and could pave the way for the development of novel therapies.
Findings published by researchers at the University of São Paulo may point to novel therapeutic targets for aging-related disorders such as neurodegenerative and cardiovascular diseases.
Experiments conducted in Brazil suggest that molecules secreted by the bacterium Akkermansia muciniphila, more abundant in Parkinson’s, promote aggregation of the protein alpha-synuclein in intestinal cells. Clumps of the protein, which are known to be associated with development of the disease, may migrate from the gut to the brain.
The startup supported by FAPESP produces all of the inputs for the test and will supply them to partner companies that will assemble kits and distribute them to retailers.
The material is not an active ingredient but an adjuvant, and was successfully tested on an influenza virus in research conducted by an international team of scientists with Brazilian participation and reported in an article in Nature.
In an article published in the journal PLOS ONE, Brazilian scientists show that the number of domestic dogs in an area influences the risk of transmission of the disease and that areas in which cases occur remain high-risk areas.
